4-Aminopyridine → HCID 22125176, compound

Participants

Reaction Steps

A solution of 100 mg (0.22 mmol) of 3-(2,6-dichlorophenyl)-7-methanesulfonyl-1-phenyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one and 200 mg (2.12 mmol) of 4-aminopyridine in 2 ml of dichloromethane was stirred at room temperature overnight. The mixture was evaporated and the residue was purified by flash column chromatography on silica gel using 10% methanol/dichloromethane for the elution. Product containing fractions were combined and evaporated to give 16 mg (15%) of 3-(2,6-dichlorophenyl)-3,4-dihydro-1-phenyl-7-[(4-pyridyl)amino]pyrimido[4,5-d]pyrimidin-2(1H)-one as an off-white solid which decomposed at 289° C.

Provenance & Evidence