HCID 22125056, compound → HCID 22125124, compound

Participants

Reaction Steps

A solution of 50 mg (0.14 mmol) of 3-(2-methoxyphenyl)-7-anilino-3,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-2(1H)-one in 15 ml of 48% aqueous hydrobromic acid was heated at reflux for 1 hour. The mixture was cooled and evaporated and the residue was triturated in hexane. The resultant solid was filtered off and dried to give 40 mg (82%) of 7-anilino-3,4-dihydro-3-(2-hydroxyphenyl)-1-methylpyrimido[4,5-d]pyrimidin-2(1H)-one as an off-white solid of melting point 192° C.

Provenance & Evidence