Hydrogen Bromide → HCID 22125168, compound

Participants

Reaction Conditions

Reaction Steps

25 mg of 1-[3-(2-aminoethyl)phenyl]-3-(2-bromophenyl)-7-(4-methoxyanilino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (prepared in Example 59) was treated with 2 ml of 40% aqueous hydrobromic acid and the mixture heated at 150° C. for 2 hours. The mixture was cooled and evaporated. The residue was triturated with hexane to afford 20 mg (80%) of 1-[3-(2-aminoethyl)phenyl]-3-(2-bromophenyl)-7-(4-hydroxyanilino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one hydrobromide as a white solid of melting point 210° C. (decomposition).

Provenance & Evidence