HCID 22125146, compound → HCID 22125113, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 250 mg (0.44 mmol) of 3-(2-bromophenyl)-3,4-dihydro-7-(methanesulfonyl)-1-[3-(methanesulfonyloxymethyl)phenyl]pyrimido[4,5-d]pyrimidin-2(1H)-one in 10 ml of dimethylformamide was treated with 111 mg (0.6 mmol) of potassium phthalimide and the mixture heated at 90° C. for 1 hour then cooled and evaporated. The residue was partitioned between 30 ml of dichloromethane and 30 ml of water. The organic phase was collected, dried over magnesium sulfate, filtered and evaporated to afford 270 mg (99%) of 3-(2-bromophenyl)-3,4-dihydro-7-(methanesulfonyl)-1-[3-(phthalimidomethyl)phenyl]pyrimido[4,5-d]pyrimidin-2(1H)-one as a white solid. [Mass spectrum (ESI) MH+ =618].

Provenance & Evidence