Aniline → HCID 22124965, compound

Participants

Reaction Conditions

Reaction Steps

1.5 g (2 mmol) of 3-(2-bromophenyl)-1-[3-(tert-butyldiphenylsilyloxymethyl)phenyl]-3,4-dihydro-7-methanesulfonyl-pyrimido[4,5-d]pyrimidin-2(1H)-one (prepared in Example 61(h)) was treated with 3 ml of aniline and the mixture heated at 180° C. for 20 minutes and cooled. The mixture was poured into 50 ml of 2M aqueous hydrochloric acid and the precipitated product filtered off, washed with water and dried to afford 1.5 g (100%) of 7-anilino-3-(2-bromophenyl)-1-[3-((tert-butyldiphenylsilyloxy)methyl)phenyl]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one as a light brown solid. [Mass spectrum (ESI) MH+ =741].

Provenance & Evidence