Aniline → HCID 54204622, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 980 mg (1.22 mmol) of 1-[3-(2-t-butyldiphenylsilyloxyethyl)phenyl]-3-(2,6-dichlorophenyl)-7-methanesulfonyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one and 5 ml of aniline was heated at 100° C. for 30 minutes. The reaction was allowed to cool then poured into 50 ml of 2M hydrochloric acid. The product was collected by filtration, washed with water (50 ml), then hexane (50 ml) and dried to give 960 mg (96%) of 7-anilino-1-[3-(2-tert-butyldiphenylsilyloxyethyl)phenyl]-3-(2,6-dichlorophenyl)-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one as a fawn solid. [Mass spectrum (ESI) MH+ =744].

Provenance & Evidence