2,4-Dichloroaniline → HCID 22125143, compound

Participants

Reaction Steps

1.97 g (2.83 mmol) of 1-[3-(2-tertbutyldiphenylsilyloxyethyl)phenyl]-3-(2,4-dichlorophenyl)-3,4-dihydro-7-methylthio-pyrimido[4,5-d]pyrimidin-2(1H)-one (prepared in a manner analogous to that described in Example 53(a)-(b) using 2,4-dichloroaniline in place of 2-chloro-6-methylaniline) was reacted with a 1M solution of tetrabutylammonium fluoride in a manner analogous to that described in Example 69. 1.3 g (100%) of 3-(2,4-dichlorophenyl)-3,4-dihydro-1-[3-(2-hydroxyethyl)phenyl]-7-methylthio-pyrimido[4,5-d]pyrimidin-2(1H)-one was isolated as a yellow solid. [Mass spectrum (ESI) MH+ =461].

Provenance & Evidence