Methylamine → HCID 22125000, compound

Participants

Reaction Steps

A solution of 120 mg (0.2 mmol) of 7-anilino-3-(2,4-dichlorophenyl)-3,4-dihydro-1-[3-(2-methanesulfonyloxyethyl)phenyl]pyrimido[4,5-d]pyrimidin-2(1H)-one in 4 ml of 40% methylamine in ethanol was heated at 50° C. for 3 hours. The reaction mixture was evaporated and the crude material purified by flash column chromatography on silica gel eluting with dichloromethane/methanol/acetic acid/water (120:14:3:2). Product containing fractions were combined and evaporated to give 18 mg (16%) of 7-anilino-3-(2,4-dichlorophenyl)-3,4-dihydro-1-[3-[2-(methylamino)ethyl]phenyl]pyrimido[4,5-d]pyrimidin-2(1H)-one as a solid of melting point 120-122° C. [Mass spectrum (ESI) MH+ =519].

Provenance & Evidence