Water → HCID 22125118, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3.2 g (14.7 mmol) of 2-ethyl-2-(3-nitro-phenyl)-butyronitrile in 50 ml of ethanol was treated with 350 mg of water-wet Raney nickel and the mixture heated to 60° C. 10 ml of hydrazine hydrate was added dropwise over 20 minutes and the reaction stirred for a further 1 hour at 60° C. The cooled mixture was filtered through hyflo filter aid and evaporated to give 2.5 g (90%) of 2-(3-amino-phenyl)-2-ethyl-butyronitrile as an orange oil. [Mass spectrum (ESI) MH+ =189].

Provenance & Evidence