Dimethyl Sulfoxide → HCID 22125044, compound

Participants

Reaction Steps

A solution of 180 mg (0.3 mmol) of 2-[3-[3-[3-(2,4-dichlorophenyl)-7-methylthio-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-1-yl]-phenyl]-propyl]-isoindole-1,3-dione in 10 ml of dichloromethane was treated with 200 mg (0.6 mmol) of 3-chloroperbenzoic acid (50% w/w water) and the mixture stirred at ambient temperature for 18 hours. 0.1 ml of dimethyl sulfoxide was added. After a further 15 minutes 10 ml of dichloromethane and 20 ml of saturated aqueous sodium bicarbonate were added. The organic phase was dried over magnesium sulfate, filtered and evaporated to give 190 mg (100%) of 2-[3-[3-[3-(2,4-dichlorophenyl)-7-methanesulfonyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-1-yl]-phenyl]-propyl]-isoindole-1,3-dione as a white solid. [Mass spectrum (ESI) MH+ =636].

Provenance & Evidence