Acetic Acid → HCID 20638251, compound

Participants

Reaction Steps

4,5α-Epoxy-3-methoxymethoxy-17-methyl-6α-((2-tetrahydropyranyl)-methoxy)-morphinan-7-ene (2.17 g, 5.08 mmol) is dissolved in water (65 ml) and glacial acetic acid (65 ml) and then stirred for 6 hours at 100° C. The volatile components are eliminated using the Rotavapor. The residue thus obtained is purified by flash chromatography (130 g of silica gel; mobile phase: methylene chloride/methanol=9:1). The product is dissolved in a mixture of water and glacial acetic acid and lyophilised. Yield: 1.55 g 4,5α-epoxy-17-methyl-6α-((2-tetrahydropyranyl)-methoxy)-morphinan-7-en-3-ol acetate (68.8%).

Provenance & Evidence