HCID 15385700, compound → HCID 15385701, compound

Participants

Reaction Steps

A solution of 4,5α-epoxy-3-methoxymethoxy-17-methyl-6α-((4-(methyloxycarbonyl)-phenyl)-methoxy)-morphinan-7-ene (1.90 g, 3.98 mmol) in MeOH (70 ml) is mixed with 10% Pd/C (1.17 g) and agitated for 0.5 hours under 1 bar of H2 pressure. The catalyst is removed by filtering through Celite and the filtrate is evaporated down. The residue is purified by flash chromatography (silica gel; mobile phase: dichloromethane: MeOH=3:1). Yield: 1.44 g 4,5α-epoxy-3-methoxymethoxy-17-methyl-6α-((4-(methyloxycarbonyl)-phenyl)-methoxy)-morphinane (75.4%).

Provenance & Evidence