Acetic Acid → HCID 15385702, compound

Participants

Reaction Conditions

Reaction Steps

4,5α-Epoxy-3-methoxymethoxy-17-methyl-6α-((4-(methyloxycarbonyl)-phenyl)-methoxy)-morphinane (1.40 g, 2.92 mmol) is dissolved with water (35 ml) and glacial acetic acid (35 ml) and then stirred for 4 hours at 100° C. The volatile components are eliminated using the Rotavapor. The residue thus obtained is purified by flash chromatography (100 g of silica gel; mobile phase: methylene chloride/methanol= 4:1). The product is dissolved in a mixture of water and glacial acetic acid and lyophilised. Yield: 1.225 g 4,5α-epoxy-17-methyl-6α-((4-(methyloxycarbonyl)-phenyl)-methoxy)-morphinan-3-ol acetate (84.7%).

Provenance & Evidence