Methoxyacetic Acid → HCID 15382175, compound

Participants

Reaction Steps

4,5α-Epoxy-3-methoxymethoxy-17-methyl-morphinan-7-en-6α-ol (2.0 g, 6.1 mmol) and 4-dimethylaminopyridine (0.8 g, 6.5 mmol) were dissolved in absolute CH2Cl2 (20 ml) and methoxy acetic acid (6.1 mmol) was added dropwise whilst cooling with ice and the resulting mixture was stirred for 2 hours at this temperature. The reaction mixture was poured onto water (50 ml), the organic phase was washed twice more with 30 ml of water and dried over MgSO4. The solvent was evaporated off and the residue separated by flash chromatography (CH2Cl2 /MeOH 9/1).

Provenance & Evidence