Acetic Acid → HCID 15385775, compound

Participants

Reaction Conditions

Reaction Steps

4,5α-epoxy-6α-((5-methoxycarbonyl-valeryl)-oxy)-3-methoxymethoxy-17-methyl-morphinane (0.43 g, 0.91 mmol) was mixed with H2O (15 ml) and glacial acetic acid (15 ml) and stirred for 6 hours at 100° C. The mixture was then evaporated down at 40° C. using a Rotavapor and the residue obtained was purified by flash chromatography (60 g silical gel; CH2Cl2 /MeOH=9/1). The product was dissolved in H2O (6 ml) and glacial acetic acid (0.6 ml) and lyophilised. Yield: 0.221 g (0.45 mmol, 49.7%).

Provenance & Evidence