HCID 20638276, compound → HCID 56976128, compound

Participants

Reaction Steps

A solution of 4,5α-epoxy-3-methoxymethoxy-6α-(4-(4-methoxyphenyl)-butyryloxy)-17-methyl-morphinan-7-ene (1.01 g, 2 mmol) in MeOH (40 ml) is mixed with 10% Pd/C (650 mg) and agitated for 1.5 hours under 1 bar of H2 pressure. The catalyst is removed by filtering through Celite and the filtrate is evaporated down. The residue is pure 4,5α-epoxy-3-methoxymethoxy-6α-(4-(4-methoxyphenyl)-butyryloxy)-17-methyl-morphinane (0.87 g, 85.7%).

Provenance & Evidence