N-Iodosuccinimide → HCID 10984692, compound

Participants

Reaction Steps

Compound (46) is prepared as described for compound (45) by proceeding from compound (18) (500 mg, 1.11 mmol) and N-iodosuccinimide (264 mg, 1.16 mmol). The duration of the reaction is 23 h. Colorless crystals (590 mg, 92%) are obtained from cyclohexane. 1H-NMR ([D6 ] DMSO): δ=1.9 (d, J=7.0, CH3), 1.15 (d, J=7.0, CH3), 2.46, 2.60, 2.89 (3 m, CH and Hα,β --C(2')), 4.06 (s, OCH3), 4.17 (m, H--C(5')), 4.27 (m, H--C(4')), 5.35 (m, H--C(3')), 6.46 (m, H--C(1')), 7.62 (s, H--C(6)), 9.55 (d, J=9.7, NH), 10.81 (d, J=9.9 HCO). Anal. calculated for C21H27JN4O7 (574.4): C, 43.91, H, 4.74, N, 9.75; found: C, 43.98, H, 4.75, N, 9.82.

Provenance & Evidence