Dimethylamine → HCID 178484513, compound

Participants

Reaction Steps

To a mixture of sodium hydride (24 mg) and N,N-dimethylformamide (4.0 ml) was added a solution of dimethylamine (54 mg) in tetrahydrofuran (320 μl) at -10° C. After stirring at room temperature for 1 hour, ethyl 2-mercapto-4-thiazole acetate (203 mg) was added to the mixture at room temperature. After stirring at room temperature for 3 hours, the mixture was poured into a mixture of water and ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel (eluent: ethyl acetate) to give N,N-dimethyl-2-mercapto-4-thiazole acetamide (72 mg).

Provenance & Evidence