Hydrochloric Acid → HCID 178433564, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-mercapto-4-methyl-5-thiazole acetate (217 mg) in tetrahydrofuran (5.0 ml) was added lithium aluminum hydride (38 mg) at ice-cooling. After stirring at 60° C. for 2 hours, the mixture was poured into a mixture of tetrahydrofuran and water, and adjusted to pH 3.0 with 1N-hydrochloric acid. The separated organic layer was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel (eluent: hexane/ethyl acetate=2/3) to give 5-(2-hydroxyethyl)-2-mercapto-4-methylthiazole (89 mg).

Provenance & Evidence