Hydrochloric Acid → HCID 178514079, compound

Participants

Reaction Steps

To a mixture of 5-amino-2-mercaptothiazole (6.61 g) in water (34 ml) and acetic acid (17 ml) was added a solution of sodium cyanate (6.50 g) in water (55 ml) at 35° C. After stirring at the same temperature for 2 hours, the solution was poured into a mixture of water, tetrahydrofuran and ethyl acetate, and adjusted to pH 3.0 with 1N-hydrochloric acid. The separated organic layer was washed with saturated sodium chloride solution (×2), dried over magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel (eluent: ethyl acetate/n-hexane) to give 5-ureido-2-mercaptothiazole (577 mg).

Provenance & Evidence