Trifluoroacetic acid → HCID 22867252, compound

Participants

Reaction Steps

To a solution of benzhydryl 7β-(2-phenylacetamido)-3-trifluoromethanesulfonyloxy-3-cephem-4-carboxylate (9.0 g) in a mixture of dichloromethane (27 ml) and anisole (9 ml) was added trifluoroacetic acid (18 ml) under ice-cooling. The mixture was stirred at the same temperature for 1 hour. The reaction mixture was poured into diisopropyl ether (380 ml) The precipitate was collected by filtration and dried to give 7β-(2-phenylacetamido)-3-trifluoromethanesulfonyloxy-3-cephem-4-carboxylic acid (7.55 g).

Provenance & Evidence