Trifluoroacetic acid → HCID 178510676, compound

Participants

Reaction Steps

To a solution of benzhydryl 7β-(2-phenylacetamido)-3-(5-tert-butoxycarbonylaminomethyl-1,3,4-thiadiazol-2-yl)thio-3-cephem-4-carboxylate (683 mg) in a mixture of dichloromethane (2.1 ml) and anisole (0.7 ml) was added trifluoroacetic acid (1.4 ml) under ice-cooling. The mixture was stirred at the same temperature for 30 minutes and at room temperature for 3 hours. The reaction mixture was poured into diisopropyl ether (70 ml). The precipitate was collected by filtration and dried over to give 7β-(2-phenylacetamido)-3-(5-aminomethyl-1,3,4-thiadiazol-2-yl)thio-3-cephem-4-carboxylic acid trifluoroacetic acid salt (525 mg).

Provenance & Evidence