Morpholine → HCID 131722178, compound

Participants

Reaction Steps

To a solution of benzhydryl 7β-(2-phenylacetamido)-3-(4-carboxymethylthiazol-2-yl)thio-3-cephem-4-carboxylate (500 mg) in N,N-dimethylformamide (10 ml) were added 1-hydroxybenzotriazole (123 mg), WSC.HCl (175 mg) and morpholine (79 mg) at room temperature. After stirring at room temperature for 2.5 hours, the solution was poured into a mixture of water and ethyl acetate, and adjusted to pH 7.0 with aqueous sodium hydrogen carbonate. The separated organic layer was washed with saturated sodium chloride solution (×3), dried over magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel (eluent: ethyl acetate/n-hexane) to give benzhydryl 7β-(2-phenylacetamido)-3-(4-morpholinocarbonylmethylthiazol-2-yl)thio-3-cephem-4-carboxylate (147 mg).

Provenance & Evidence