Hydrochloric Acid → HCID 178433976, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 7β-[2-(5-chloro-2-formylaminothiazol-4-yl)acetamido]-3-(5-methyl-1,3,4-thiadiazol-2-yl)thio-3-cephem-4-carboxylic acid (380 mg), methanol (4 ml) and tetrahydrofuran (4 ml) was conc-hydrochloric acid (153 μl). The mixture was stirred for 5 hours at 35° C. The reaction mixture was added to a mixture of ethyl acetate (20 ml) and ice-water (50 ml). To the aqueous solution was added ethyl acetate (20 ml). The mixture was adjusted to pH 7 with 1N-sodium hydroxide solution. To the separated aqueous solution was added ethyl acetate (20 ml). The mixture was adjusted to pH 2 with 1N-hydrochloric acid. The precipitate was collected by filtration, washed with ethyl acetate, and dried to give 7β-[2-(2-amino-5-chlorothiazol-4-yl)acetamido]-3-(5-methyl-1,3,4-thiadiazol-2-yl)thio-3-cephem-4-carboxylic acid (188 mg).

Provenance & Evidence