Sodium Hydroxide → HCID 178525364, compound

HRID 1858531Notes

Reaction equation

HRID 1858531 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][C@@H:10]1[C:30](=[O:31])[N:12]2[C:13]([C:27]([OH:29])=[S:28])=[C:14]([C:17]3[S:18][CH:19]=[C:20]([CH2:22][CH2:23][C:24]([OH:26])=[O:25])[N:21]=3)[CH2:15][S:16][C@H:11]12)=[O:8].[OH-].[Na+:33]>O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][C@@H:10]1[C:30](=[O:31])[N:12]2[C:13]([C:27]([O-:29])=[S:28])=[C:14]([C:17]3[S:18][CH:19]=[C:20]([CH2:22][CH2:23][C:24]([OH:26])=[O:25])[N:21]=3)[CH2:15][S:16][C@H:11]12)=[O:8].[Na+:33].[Na+:33].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][C@@H:10]1[C:30](=[O:31])[N:12]2[C:13]([C:27]([O-:29])=[S:28])=[C:14]([C:17]3[S:18][CH:19]=[C:20]([CH2:22][CH2:23][C:24]([OH:26])=[O:25])[N:21]=3)[CH2:15][S:16][C@H:11]12)=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178525363HCID 178525363, compound

Product 1

HCID 178525364HCID 178525364, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 7β-[2-(2-thienyl)acetamido]-3-[4-(2-carboxyethyl)thiazol-2-yl]thio-3-cephem-4-carboxylic acid (100 mg) in water (50 ml) was added 0.1 mol/l-sodium hydroxide solution (3.9 ml). The solution was lyophilized to give disodium 7β-[2-(2-thienyl)acetamido]-3-[4-(2-carboxyethyl)thiazol-2-yl]thio-3-cephem-4-carboxylate (108.3 mg).

Sources & evidence

ORD record
ord-c3a93fdf2aa5485e98186e5a27490dbd
Source dataset
uspto-grants-2000_11
Patent number
US06150351

Reaction notes

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