Sodium Hydroxide → HCID 178525232, compound

HRID 1858532Notes

Reaction equation

HRID 1858532 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C@@H:11]2[C:30](=[O:31])[N:13]3[C:14]([C:27]([OH:29])=[S:28])=[C:15]([C:18]4[S:19][CH:20]=[C:21]([CH2:23][C:24]([OH:26])=[O:25])[N:22]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:33]>O.CO.CC(C)=O>[C:1]1([CH2:7][C:8]([NH:10][C@@H:11]2[C:30](=[O:31])[N:13]3[C:14]([C:27]([O-:29])=[S:28])=[C:15]([C:18]4[S:19][CH:20]=[C:21]([CH2:23][C:24]([OH:26])=[O:25])[N:22]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+:33].[Na+:33].[C:1]1([CH2:7][C:8]([NH:10][C@@H:11]2[C:30](=[O:31])[N:13]3[C:14]([C:27]([O-:29])=[S:28])=[C:15]([C:18]4[S:19][CH:20]=[C:21]([CH2:23][C:24]([OH:26])=[O:25])[N:22]=4)[CH2:16][S:17][C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 2

HCID 14798Sodium HydroxideHCID 178525231HCID 178525231, compound

Product 1

HCID 178525232HCID 178525232, compound

Reagents, catalysts & solvents 3

HCID 180AcetoneSolventHCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

To a solution of 7β-(2-phenylacetamido)-3-(4-carboxymethylthiazol-2-yl)thio-3-cephem-4-carboxylic acid (100 mg) in water (50 ml) was added 0.1 mol/l-sodium hydroxide solution (4.06 ml). The solution was lyophilized. The above obtained powder was dissolved in a mixture of methanol (0.5 ml) and acetone (1.3 ml) under stirring at 30° C. The stirring was continued for 2 hours at room temperature to give crystals, which were collected by filtration and dried to give disodium 7β-(2-phenylacetamido)-3-(4-carboxymethylthiazol-2-yl)thio-3-cephem-4-carboxylate (69.1 mg).

Workup

  1. customThe above obtained powder
  2. customto give crystals, which
  3. filtrationwere collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-b63e397f33a348ada51709327d22511a
Source dataset
uspto-grants-2000_11
Patent number
US06150351

Reaction notes

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