HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Chloromethyl)-2,3-dihydro-1,4-benzodioxine → HCID 54062527, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Chloromethyl)-2,3-dihydro-1,4-benzodioxine | HCID 5230287 | — |
| Reactant | Tert-butyl 4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate | HCID 45074236 | — |
| Product | HCID 54062527 | HCID 54062527 | — |
Reaction Steps
In an analogous manner to that described in Example 1(g), by alkylating tert-butyl (3RS,4RS)-4-(4-fluorophenyl)-3-hydroxy-piperidine-1-carboxylate with 6-chloromethyl-2,3-dihydro-benzo[1,4]dioxin [Brit. Pat. 566732 (1943)] there was obtained tert-butyl (3RS,4RS)-3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethoxy)-4-(4-fluorophenyl)-piperidine-1-carboxylate as a colourless solid; MS: 444 (M+H)+ ;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06150526 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-f72b9800f270455cbee68b8019c9903d |
| Source note | uspto-grants-2000_11 |