HRID18586

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75644

Cyclopropylmethanol

C4H8O

结构：O=C(Cn1c(C(=O)NC2CCN(C3CC3)CC2)nc2c(C(=O)O)cccc21)Nc1ccc(Cl)cn1

HCID68615990

未命名化合物

PRODUCTS

生成物

结构：O=C(Cn1c(C(=O)NC2CCN(C3CC3)CC2)nc2c(C(=O)OCC3CC3)cccc21)Nc1ccc(Cl)cn1

HCID67012846

未命名化合物

PROCEDURE

实验过程

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-2-(1-cyclopropyl-piperidin-4-ylcarbamoyl)-1H-benzoimidazole-4-carboxylic acid cyclopropylmethyl ester was prepared by a procedure according to example 69 starting from 589.0 mg (1.19 mmol) 1-[(5-chloro-pyridin-2-ylcarbamoyl)-methyl]-2-(1-cyclopropyl-piperidin-4-ylcarbamoyl)-1H-benzoimidazole-4-carboxylic acid and 1.92 mL (23.8 mmol) cyclopropyl-methanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ac6d5208cab4418181094428aa4f4c12
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07741341B2
来源说明: uspto-grants-2010_06

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([CH2:11][N:12]2[C:16]3[CH:17]=[CH:18][CH:19]=[C:20]([C:21]([OH:23])=[O:22])[C:15]=3[N:14]=[C:13]2[C:24](=[O:35])[NH:25][CH:26]2[CH2:31][CH2:30][N:29]([CH:32]3[CH2:34][CH2:33]3)[CH2:28][CH2:27]2)=[O:10])=[N:6][CH:7]=1.[CH:36]1([CH2:39]O)[CH2:38][CH2:37]1>>[CH:36]1([CH2:39][O:22][C:21]([C:20]2[C:15]3[N:14]=[C:13]([C:24](=[O:35])[NH:25][CH:26]4[CH2:31][CH2:30][N:29]([CH:32]5[CH2:34][CH2:33]5)[CH2:28][CH2:27]4)[N:12]([CH2:11][C:9](=[O:10])[NH:8][C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=4)[C:16]=3[CH:17]=[CH:18][CH:19]=2)=[O:23])[CH2:38][CH2:37]1