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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1858612Generated: October 26, 2026

2-Bromomethylnaphthalene → tert-butyl (3RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

https://huagongshe.com/reaction/1858612

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-BromomethylnaphthaleneHCID 70320—
Reactanttert-butyl (3RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-hydroxy-piperidine-1-carboxylateHCID 86604399—
Producttert-butyl (3RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylateHCID 53757216—

Reaction Steps

Alkylation of tert-butyl (3RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-hydroxy-piperidine-1-carboxylate with 2-bromomethylnaphthalene analogously to the procedure described in Example 22(i) gave tert-butyl (3RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate as a light yellow resin; MS: 516 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06150526
Source datasetuspto-grants-2000_11
ORD IDord-df637780f676438ebacb641ff014185f
Source noteuspto-grants-2000_11