HRID1858622

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22126520

未命名化合物

反应SMILES：COC(=O)c1cccc(C2CCN(C(=O)OC(C)(C)C)CC2O)c1

HCID53898470

未命名化合物

PRODUCTS

产物

反应SMILES：COC(=O)c1cccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2cc(OCc3ccccc3)c3ccccc3c2)c1

HCID54179161

未命名化合物

PROCEDURE

实验过程

In an analogous manner to that described in Example 22(i), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-(3-methoxycarbonyl-phenyl)-piperidine-1-carboxylate with 1-benzyloxy-3-chloromethylnaphthalene there was obtained tert-butyl (3RS,4RS)-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(3-methoxycarbonyl-phenyl)-piperidine-1-carboxylate as a pale yellow amorphous powder; MS: 582 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-4f9ecc7804ba4e56a2a58b01d294cae3
来源数据集: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06150526
来源说明: uspto-grants-2000_11

反应SMILES

[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16][CH3:17])=[O:15])[CH:9]=2)[CH2:6][CH2:5][N:4]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:3]1.[CH2:25]([O:32][C:33]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:36]=[C:35]([CH2:43]Cl)[CH:34]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([O:32][C:33]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:36]=[C:35]([CH2:43][O:1][CH:2]2[CH:7]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16][CH3:17])=[O:15])[CH:9]=3)[CH2:6][CH2:5][N:4]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:3]2)[CH:34]=1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1