HRID1858698

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2724141

Tetra-n-butylammonium fluoride

C16H36FN

反应SMILES：CCCC1CN(C(=O)OCC[Si](C)(C)C)CC(OCc2cc(OCc3ccccc3)c3ccccc3c2)C1c1ccc(F)cc1

HCID86604430

未命名化合物

PRODUCTS

产物

反应SMILES：CCCC1CNCC(OCc2cc(OCc3ccccc3)c3ccccc3c2)C1c1ccc(F)cc1

HCID10184545

未命名化合物

PROCEDURE

实验过程

In an analogous manner to that described in Example 5, by treating 2-trimethylsilanylethyl (3RS,4RS,5SR)-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(4-fluoro-phenyl)-5-propyl-piperidine-1-carboxylate with tetrabutylammonium fluoride solution there was obtained (3RS,4RS,5SR)-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(4-fluoro-phenyl)-5-propyl-piperidine as an almost colourless solid, MS: 484 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-bfe0f167d794475189d16113372a8508
来源数据集: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06150526
来源说明: uspto-grants-2000_11

反应SMILES

[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[C:11]([CH2:19][O:20][CH:21]2[CH:26]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)[CH:25]([CH2:34][CH2:35][CH3:36])[CH2:24][N:23](C(OCC[Si](C)(C)C)=O)[CH2:22]2)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[C:11]([CH2:19][O:20][CH:21]2[CH:26]([C:27]3[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=3)[CH:25]([CH2:34][CH2:35][CH3:36])[CH2:24][NH:23][CH2:22]2)[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1