Trichlorourethan → HCID 22128525, compound

HRID 1858719Notes

Reaction equation

HRID 1858719 reaction equation
C(=O)(OCC(Cl)(Cl)Cl)N.C(=O)([O-])OCC(Cl)(Cl)Cl.[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]2[CH2:32][CH:31]3[N:33](C(OCC(Cl)(Cl)Cl)=O)[CH:28]([CH2:29][CH2:30]3)[CH:27]2[O:42]C(OCC(Cl)(Cl)Cl)=O)=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:21]=[CH:22][C:23]([CH:26]2[CH2:32][CH:31]3[NH:33][CH:28]([CH2:29][CH2:30]3)[CH:27]2[OH:42])=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 7883TrichlorourethanHCID 22177517HCID 22177517, compoundHCID 54074670HCID 54074670, compound

Product 1

HCID 22128525HCID 22128525, compound

Procedure

By cleavage of the 2,2,2-trichloroethyl carbamate and 2,2,2-trichloroethyl carbonate from 2,2,2-trichloro-ethyl (1RS,2RS,3RS,5RS)-3-(4-fluoro-phenyl)-2-(2,2,2-trichloro-ethoxycarbonyloxy)-8-aza-bicyclo[3.2.1]octane-8-carboxylate in an analogous manner to that described in Example 12(d) there was obtained (1RS,2RS,3RS,5RS)-3-(4-fluoro-phenyl)-8-aza-bicyclo[3.2.1]octan-2-ol as a colourless solid; MS: 221 (M)+.

Sources & evidence

ORD record
ord-07bceffe9a1849e78d802a44708d9ee8
Source dataset
uspto-grants-2000_11
Patent number
US06150526

Reaction notes

Loading…