2-(3-Bromopropoxy)tetrahydro-2H-pyran → HCID 22128473, compound

HRID 1858801Notes

Reaction equation

HRID 1858801 reaction equation
C([C:5]1[C:6]([O:12][CH3:13])=[C:7]([SH:11])[CH:8]=[CH:9][CH:10]=1)(C)(C)C.Br[CH2:15][CH2:16][CH2:17][O:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][O:20]1>>[CH3:13][O:12][C:6]1[CH:5]=[CH:10][CH:9]=[CH:8][C:7]=1[S:11][CH2:15][CH2:16][CH2:17][O:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][O:20]1

Participants

3

Reactant 2

HCID 27779882-(3-Bromopropoxy)tetrahydro-2H-pyranHCID 22128316HCID 22128316, compound

Product 1

HCID 22128473HCID 22128473, compound

Procedure

In an analogous manner to that described in Example 44 e), by alkylating tert-butyl 2-methoxy-thiophenol with (RS)-2-(3-bromo-propoxy)-tetrahydro-pyran there was obtained (RS)-2-[3-(2-methoxy-phenylsulphanyl)-propoxy]-tetrahydro-pyran.

Sources & evidence

ORD record
ord-ad568b8a59e241bbab08f1a3de99ea1e
Source dataset
uspto-grants-2000_11
Patent number
US06150526

Reaction notes

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