HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Chloromethyl)-4-(methylthio)benzene → HCID 53938047, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Chloromethyl)-4-(methylthio)benzene | HCID 70128 | — |
| Reactant | Tert-butyl 4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate | HCID 45074236 | — |
| Product | HCID 53938047 | HCID 53938047 | — |
Reaction Steps
In an analogous manner to that described in Example 1(g), by alkylating tert-butyl (3RS,4RS)-4-(4-fluoro-phenyl)-3-hydroxy-piperidine-1-carboxylate [Example 3(b)] with 4-methylthio-benzyl chloride [J.Org.Chem. (1988),53(3), 561-569] there was obtained tert-butyl (3RS,4RS)-4-(4-fluoro-phenyl)-3-(4-methylsulphanyl-benzyloxy)-piperidine-1-carboxylate as a colourless oil; MS: 432 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06150526 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-c646ea6a04384dfeaff8b88aba89f379 |
| Source note | uspto-grants-2000_11 |