Acetic Anhydride → HCID 22121938, compound

HRID 1858911Notes

Reaction equation

HRID 1858911 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[S:12]([N:15]2[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)(=[O:14])=[O:13])[CH:5]=[N:4][CH:3]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>N1C=CC=CC=1>[C:22]([N:18]1[CH2:19][CH2:20][CH2:21][N:15]([S:12]([C:10]2[CH:9]=[CH:8][CH:7]=[C:6]3[C:11]=2[C:2]([CH3:1])=[CH:3][N:4]=[CH:5]3)(=[O:14])=[O:13])[CH2:16][CH2:17]1)(=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 9951687HCID 9951687, compound

Product 1

HCID 22121938HCID 22121938, compoundYield 74.6%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
60 °C

Procedure

To 30 ml of a suspension prepared by suspending 2.25 g of hexahydro-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine in pyridine was added 2.0 g of acetic anhydride, and the mixture was stirred at 60° C. for 30 minutes. This reaction mixture was concentrated, made basic with sodium hydrogencarbonate/H2O, and extracted with chloroform. The extract was dried and concentrated to provide 1.91 g of 1-acetyl-hexahydro-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine as oil.

Workup

  1. concentrationThis reaction mixture was concentrated
  2. extractionextracted with chloroform
  3. customThe extract was dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-776d3623f7564a4391246a7fc0433d08
Source dataset
uspto-grants-2000_11
Patent number
US06153608

Reaction notes

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