HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroisoquinoline → 1-[(4-Chloro-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroisoquinoline | HCID 640974 | — |
| Reactant | Tert-butyl 1,4-diazepane-1-carboxylate | HCID 2756058 | — |
| Reactant | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| Product | 1-[(4-Chloro-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride | HCID 22121939 | — |
Reaction Steps
Using 2.08 g of 4-chloroisoquinoline (synthesized in accordance with J. Org. Chem., 1961, 26, 468), 4-chloro-5-chlorosulfonylisoquinoline was synthesized as in Reference Example 1. Then, 1.30 g of this compound was reacted with 1.20 g of 1-(tert-butoxycarbonyl)-hexahydro-1H-1,4-diazepine and the reaction mixture was after-treated in the same manner as in Example 1 to provide 0.80 g of the objective compound (white crystals).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153608 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-a5506e70edf642b7b061a65f0bcae6f7 |
| Source note | uspto-grants-2000_11 |