tert-Butyl 3-methylpiperazine-1-carboxylate → HCID 22121892, compound

HRID 1858915Notes

Reaction equation

HRID 1858915 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][NH:11][CH:10]([CH3:14])[CH2:9]1)=O)(C)(C)C.[Cl:15][S:16]([C:19]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:20]=1[C:21]([CH3:29])=[CH:22][N:23]=[CH:24]2)(=[O:18])=[O:17]>>[ClH:15].[ClH:15].[CH3:14][CH:10]1[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[S:16]([C:19]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:20]=1[C:21]([CH3:29])=[CH:22][N:23]=[CH:24]2)(=[O:17])=[O:18]

Participants

3

Reactant 2

HCID 2756810tert-Butyl 3-methylpiperazine-1-carboxylateHCID 154871104-Methylisoquinoline-5-sulfonyl chloride

Product 1

HCID 22121892HCID 22121892, compoundYield 78.2%

Procedure

Using 0.40 g of 1-(tert-butoxycarbonyl)-3-methylpiperazine and 0.49 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.3 g of the objective compound (white crystals).

Sources & evidence

ORD record
ord-984c6b615cb248618167c00bf4f1281a
Source dataset
uspto-grants-2000_11
Patent number
US06153608

Reaction notes

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