2,6-Dimethylpiperazine → HCID 22121959, compound

HRID 1858916Notes

Reaction equation

HRID 1858916 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH:4]([CH3:8])[NH:3]1.[Cl:9][S:10]([C:13]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:14]=1[C:15]([CH3:23])=[CH:16][N:17]=[CH:18]2)(=[O:12])=[O:11]>>[ClH:9].[ClH:9].[CH3:8][CH:4]1[NH:3][CH:2]([CH3:1])[CH2:7][N:6]([S:10]([C:13]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:14]=2[C:15]([CH3:23])=[CH:16][N:17]=[CH:18]3)(=[O:11])=[O:12])[CH2:5]1

Participants

3

Reactant 2

HCID 660562,6-DimethylpiperazineHCID 154871104-Methylisoquinoline-5-sulfonyl chloride

Product 1

HCID 22121959HCID 22121959, compoundYield 120.6%

Procedure

Using 0.23 g of 2,6-dimethylpiperazine and 0.48 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.47 g of the objective compound (white crystals).

Sources & evidence

ORD record
ord-487ebf23649c4182bee59d6255f5ee01
Source dataset
uspto-grants-2000_11
Patent number
US06153608

Reaction notes

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