HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylisoquinoline-5-sulfonyl chloride → HCID 9885022, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylisoquinoline-5-sulfonyl chloride | HCID 15487110 | — |
| Reactant | 2-Methyl-1,4-diazepane | HCID 21646180 | — |
| Reactant | HCID 22121934 | HCID 22121934 | — |
| Product | HCID 9885022 | HCID 9885022 | 15.2% |
Reaction Steps
Using 1.07 g of 4-(tert-butoxycarbonyl)-hexahydro-2-methyl-1H-1,4-diazepine prepared by protecting the 4-position of hexahydro-2-methyl-1H-1,4-diazepine (2.8 g) synthesized in accordance with J. Med. Chem., 1990, 33, 142 and 1.21 g of 5-chlorosulfonyl-4-methylisoquinoline, the procedure of Example 1 was otherwise repeated to provide 0.27 g of the objective compound (white crystals).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153608 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-efab0b3bee3247feab9db11b2600f02c |
| Source note | uspto-grants-2000_11 |