5-Methoxyindole → HCID 22122073, compound

Participants

Reaction Steps

A solution of 5-methoxyindole (3.68 mmole), 4-[4-(phenylmethyl)-1-piperazinyl]cyclohexanone (3.68 mmole), and pyrrolidine (0.25 ml) in ethanol (10 ml) was heated at reflux for 96 hr. The solution was concentrated in vacuo and the residue purified by chromatography on silica eluting with ethyl acetate in hexane to give the product which was converted to the fumarate salt in ethyl acetate (38.4%, mp: 199-200° C.). Calc'd for C26H31N3O.2C2H2O2 : C, 64.45%; H, 6.21%; N, 6.64%. Found: C, 64.42%; H, 6.21%; N, 6.61%.

Provenance & Evidence