5-Fluoroindole → HCID 22122071, compound

HRID 1858941Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[C:11]1([CH2:17][CH:18]2[CH2:23][CH2:22][N:21]([CH:24]3[CH2:29][CH2:28][C:27](=O)[CH2:26][CH2:25]3)[CH2:20][CH2:19]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:27]1[CH2:28][CH2:29][CH:24]([N:21]2[CH2:22][CH2:23][CH:18]([CH2:17][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:19][CH2:20]2)[CH2:25][CH:26]=1

Participants

Reactant 2

HCID 678615-Fluoroindole

HCID 15338142HCID 15338142, compound

Product 1

HCID 22122071HCID 22122071, compoundYield 87.1%

Procedure

This compound was prepared from 5-fluoroindole and 4-[4-(phenylmethyl)-1-piperidinyl]cyclohexanone by the method described in Example 48 to give the product (87.1%, mp:72-74° C.). Calc'd for C26H29FN2.0.15C2H5OH: C, 79.83%; H, 7.72%; N, 7.04%. Found: C, 79.89%; H, 7.63%; N, 7.09%.

Sources & evidence

ORD record: ord-7fc02e65ce0e47d3a05e7d4ce28c4feb
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06153611

Reaction notes

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