Potassium Carbonate → 1-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]-4-[(2,5-difluorophenyl)methyl]piperazine

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-(Bromomethyl)-1,4-difluorobenzene	HCID 522830	—
Reactant	1-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]piperazine	HCID 22122062	—
Product	1-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]-4-[(2,5-difluorophenyl)methyl]piperazine	HCID 22122070	—

Reaction Steps

The title compound was prepared from 2,5-difluorobenzyl bromide (0.21 g, 1 mmole), and 1-[4-(1,3-benzodioxol-5-yl)-3-cyclohexen-1-yl]piperazine (0.29 g, 1 mmole), and excess powdered K2CO3 as described in example 45 to give the product (62%, mp: 108-109° C.). Calc'd for C24H26F2N2O2 : C, 69.88%; H, 6.35%; N, 6.79%. Found: C, 69.82; H, 6.35%; N, 6.69%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06153611
Source dataset	uspto-grants-2000_11
ORD ID	ord-def3c8503a4040c5b3bac135c7ec0b68
Source note	uspto-grants-2000_11