1-Benzylpiperazine → HCID 178505745, compound

HRID 1858947Notes

Reaction equation

HRID 1858947 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:15]1([CH2:21][N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][C@H:11]([N:25]3[CH2:26][CH2:27][N:22]([CH2:21][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:23][CH2:24]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 128343224-(4-Fluorophenyl)cyclohexan-1-one

Product 1

HCID 178505745HCID 178505745, compoundYield 22%

Procedure

A mixture of 4-(4-fluorophenyl)cyclohexanone (7.8 mmole) and 1-(phenylmethyl)piperazine (7.8 mmole) were reacted as described in Example 8. The crude isomer mixture was purified as described in Example 62. Concentration of the fractions containing the more polar isomer gave the trans product (22%, mp: 106-106° C.). Calc'd for C23H29FN2 : C, 78.38%; H, 8.30%; N, 7.95%. Found: C, 78.02; H, 8.20%; N, 7.90%.

Workup

  1. customwere reacted
  2. customThe crude isomer mixture was purified
  3. additionConcentration of the fractions containing the more polar isomer

Sources & evidence

ORD record
ord-c6b99fcdcaae4555a0eb1f20637fc618
Source dataset
uspto-grants-2000_11
Patent number
US06153611

Reaction notes

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