3-Methoxybenzyl chloride → HCID 178490267, compound

HRID 1858949Notes

Reaction equation

HRID 1858949 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][C@H:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25]Cl>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:9][CH2:10][C@H:11]([N:14]3[CH2:15][CH2:16][N:17]([CH2:25][C:24]4[CH:27]=[CH:28][CH:29]=[C:22]([O:21][CH3:20])[CH:23]=4)[CH2:18][CH2:19]3)[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 699943-Methoxybenzyl chlorideHCID 178505742HCID 178505742, compound

Product 1

HCID 178490267HCID 178490267, compound

Procedure

The title compound was prepared from trans 1-[4-(4-fluorophenyl)-1-cyclohexyl]piperazine (0.39 g, 1.5 mmole) and 3-methoxybenzyl chloride (0.22 g, 1.5 mmole) by the method described in example 45 to give the product (61%, mp: 84-85° C.). Calc'd for C24H31FN2O: C, 75.36%; H, 8.17%; N, 7.33%. Found: C, 75.53%; H, 8.23%; N, 7.30%.

Sources & evidence

ORD record
ord-8f217eb0b8934cc988051ad8cee21846
Source dataset
uspto-grants-2000_11
Patent number
US06153611

Reaction notes

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