反应详情

To a heterogeneous slurry of 2-chloro-5-ethylaniline (1.6 g, 10 mmol) in 60 mL of water at 4° C. was added solid BrCN (0.848 g, 8 mmol) slowly. After 5 minutes the cooling bath was removed and the heterogeneous reaction mixture was stirred at room temperature for 24 hours to yield the product in water suspension. The precipitates were collected by filtration, washed with water (100 mL), and dried under vacuum to yield the pure title compound (1.45 g, 80% yield).

1. customAfter 5 minutes the cooling bath was removed
2. customto yield the product in water suspension
3. filtrationThe precipitates were collected by filtration
4. washwashed with water (100 mL)
5. customdried under vacuum