4-Nitrobenzoyl chloride → HCID 53679091, compound

HRID 1859013Notes

Reaction equation

HRID 1859013 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]([OH:24])([C@H:16]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[N+:25]([C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1)([O-:27])=[O:26]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]([OH:24])([C@H:16]([N:18]1[CH2:19][CH2:20][N:21]([C:32](=[O:33])[C:31]2[CH:30]=[CH:29][C:28]([N+:25]([O-:27])=[O:26])=[CH:36][CH:35]=2)[CH2:22][CH2:23]1)[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1

Participants

3

Reactant 2

HCID 85024-Nitrobenzoyl chlorideHCID 15481711HCID 15481711, compound

Product 1

HCID 53679091HCID 53679091, compoundYield 92%

Procedure

The example 14 was prepared form the reaction of piperazino derivative 2 and 4-nitrobenzoyl chloride by following the similar procedure described for the example 12. After column purification the product was obtained as brown prisms in 92% yield.

Workup

  1. customThe example 14 was prepared form
  2. customAfter column purification the product
  3. customwas obtained as brown prisms in 92% yield

Sources & evidence

ORD record
ord-314d64545b154839a5688856b15cb82e
Source dataset
uspto-grants-2000_11
Patent number
US06153616

Reaction notes

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