4-Toluenesulfonyl chloride → HCID 54417239, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of piperazinyl compound 2 (146 mg, 0.43 mmol) and triethylamine in dichloromethane (5 ml) was added p-toluenesulphonyl chloride (51 mg, 0.45 mmol) in dichloromethane (1 ml) at 0° C. The reaction mixture was stirred at 0° C. for 15 minutes and 2 h at room temperature. Then the reaction mixture was diluted with chloroform (15 ml), washed with water, brine and dried over sodium sulphate. The solvent was removed under reduced pressure and the resulting product was purified on a column of silica gel (CHCl3 /MeOH; 98:2 ) to give the title compound as a colorless solid (75 mg, 16%).

Provenance & Evidence