4-Bromo-1,2-dichlorobenzene → 2-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

HRID 1859022Notes

Reaction equation

HRID 1859022 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][N:3]=1.[Cl:12][C:13]1[CH:14]=[C:15](Br)[CH:16]=[CH:17][C:18]=1[Cl:19]>>[Cl:1][C:2]1[N:3]=[C:4]([C:16]2[CH:15]=[CH:14][C:13]([Cl:12])=[C:18]([Cl:19])[CH:17]=2)[CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[N:7]=1

Participants

3

Reactant 2

HCID 290134-Bromo-1,2-dichlorobenzeneHCID 27739122-Chloro-4-(trifluoromethyl)pyrimidine

Product 1

HCID 154777402-Chloro-4-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

Procedure

4A was prepared from 2-chloro-4-trifluoromethylpyrimidine and 3,4-dichlorobromobenzene by the method reported for 1A. (Method A) 1H NMR 1H,(8.29,8.28,d) 1H,(8.01,8.00,7.98,7.97,dd) 1H, (7.92,s) 1H,(7.66,7.63,d).

Sources & evidence

ORD record
ord-bb9fb563cee24594ae3f4a45e8875583
Source dataset
uspto-grants-2000_11
Patent number
US06153619

Reaction notes

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