HRID1859024

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5960

L-Aspartic acid

C4H7NO4

结构：CCN(CC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)O)C(=O)OC(C)(C)C

HCID12991452

未命名化合物

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F.On1nnc2ccccc21

HCID86630130

未命名化合物

PRODUCTS

生成物

结构：CCN(CC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O)C(=O)OC(C)(C)C

HCID12991453

未命名化合物

PROCEDURE

实验过程

As a specific example of HOBT/TBTU Method, when the general procedure is followed, 10 g (24.5 mmole) of BOC-N(Et)Gly-(L)-Asp(OBzl)-OH is used, then 9.3 g of BOC-N(Et)Gly-(L)-Asp(OBzl)-(L)-Cha-NH2 is prepared (96.1A % pure, 1.77A % diastereomer at Asp), a 67.7% theoretical yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-814e9b285abc43a8905f3de16bbcc7a1
来源数据集: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06153588
来源说明: uspto-grants-2000_11

反应 SMILES

C1C=[CH:3][C:4]2[N:9](O)N=[N:7][C:5]=2C=1.CN(C(ON1N=N[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[C:33]([N:40]([CH2:60][CH3:61])[CH2:41][C:42]([NH:44][C@H:45]([C:57]([OH:59])=O)[CH2:46][C:47](=[O:56])[O:48][CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1)=[O:43])([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34].N[C@H](C(O)=O)CC(=O)[OH:66]>>[C:33]([N:40]([CH2:60][CH3:61])[CH2:41][C:42]([NH:44][C@H:45]([C:57]([NH:9][C@H:4]([C:5]([NH2:7])=[O:66])[CH2:3][CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1)=[O:59])[CH2:46][C:47](=[O:56])[O:48][CH2:49][C:50]1[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=1)=[O:43])([O:35][C:36]([CH3:38])([CH3:39])[CH3:37])=[O:34]