HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichlorophenylacetic acid → N-[(3,4dichlorophenyl)acetyl]-L-alanine iso-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichlorophenylacetic acid | HCID 79874 | — |
| Reactant | 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride | HCID 86584981 | — |
| Product | N-[(3,4dichlorophenyl)acetyl]-L-alanine iso-butyl ester | HCID 15481766 | — |
Reaction Steps
Following General Procedure B' and using 3,4-dichlorophenylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example B' above), the title compound was prepared as a solid having a melting point of 81°-83° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06153652 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-5e4826ca02044931a2ca628d4f5ec2b2 |
| Source note | uspto-grants-2000_11 |